losangelesnewstoday.com
losangelesnewstoday.com October 18, 2017


Gene-edited embryo study: A 'milestone' - or a route toward 'genetic upgrades'?

04 August 2017, 12:26 | Violet Powell

AP Top Stories August 2 A

First Human Embryos Edited in US

US scientists have succeeded in altering the genes of a human embryo to correct a disease-causing mutation, making it possible to prevent the defect from being passed on to future generations.

In a world first, USA researchers announced on Wednesday in the science journal Nature they had used the controversial gene editing technique, CRISPR-Cas9, to correct a mutation for a heart condition in embryos.

His team corrected a faulty gene that causes a heart condition, hypertrophic cardiomyopathy, this is the most common cause of sudden death in young athletes.

Experts have hailed research raising the prospect of Britain pioneering the use of human embryo gene editing to wipe out inherited diseases as "remarkable" and a "major advance".

American scientists have accomplished a major first: For the first time on U.S. soil, a human embryo has been genetically modified.

"It feels a bit like a "one small step for [hu] mans, one giant leap for [hu] mankind" moment", Jennifer Doudna, a biochemist who helped discover the gene-editing method used, called CRISPR-Cas9, said in an e-mail.

The experiments were privately funded; US tax dollars aren't allowed for embryo research.

But while the procedure is considered to be the first of its kind, human trials are not now allowed in the United States. The embryos were created from eggs donated by healthy women, which were artificially inseminated with sperm from males carrying the mutation.

CRISPR-Cas9 works as a pair of genetic scissors created to cut the DNA near the position of the mutation and correct the hypertrophic cardiomyopathy mutation carried in the DNA of the sperm, it said.

[Recently, ] reports emerged that scientists in OR had used gene-editing technology, known as CRISPR-Cas9, to edit a human embryo.

Teen driver's sister killed in Los Banos crash live on Instagram
Sanchez is seen broadcasting herself live on Instagram as she drives down the road and raps along with the music. Obdulia is now in the Merced County Jail on charges of vehicular manslaughter while under the influence and DUI.

The researchers found that 72.4 percent of the embryos, not 50 percent as would have been expected, were free of the errant gene.

Mitalipov and his colleagues were able to avoid the previous mistakes made by the Chinese scientists by injecting the Cas9 enzyme (which acts as a sort of scissors for DNA fragments) into the sperm and eggs at the same time. Natural DNA-repair mechanisms in the cell follow up by filling in the missing pieces.

To increase the success rate, his team introduced the genome editing components along with sperm from a male with the targeted gene defect during the in vitro fertilization process. "Moreover, if such embryos were to grow up, as will doubtless occur in the future, there are likely to be unintended effects from modifying their genes", Fr. Pacholczyk continued.

The embryo studies were conducted in the United States of America where this procedure is legal, in adherence to guidelines established by OHSU's Institutional Review Board and additional ad-hoc committees established for scientific and ethical review.

And Congress has banned the US Food and Drug Administration (FDA) from even considering the possibility of human clinical trials involving embryos with edited inherited genes.

But these embryos weren't actually allowed to develop beyond a few days.

As a biologist, understanding if this technology is safe, and whether a healthy human baby can be born from a genetically modified human embryo seems unanswerable right now.

Embryos' self-healing DNA came as a surprise, because gene editing in other types of cells usually requires an external template, Mitalipov says.

But the new embryo experiments were striking for both their efficacy and a lack of adverse events like mutations in other parts of the embryos' genomes. But the finding could be good news for those concerned about designer babies, because embryos may reject attempts to add new traits.



Other News

Trending Now

Questions Face UK Plan to Ban Gasoline, Diesel LVs
There is still no clarity on whether incentives for scrapping old diesel cars be introduced alongside the rest of the plan. Electric vehicle customers receive up to £4,500, while hybrid buyers receive a £2,500 contribution towards the auto .

Peaty shatters own world record in 50m breaststroke
I was just going out there just to qualify for the semis. "I just dived in tonight and was like "I feel good". Just lining it all up beforehand and making sure I can get everywhere I need to go pretty quickly.

Yoan Moncada and Willy Garcia collided in a brutal outfield play
The Sox trailed the Blue Jays 3-0 at the time of the collision, and the bases were loaded when Barney hit James Shields' fastball. However, the White Sox have just released statements that sure seem like best-case scenarios - so far - for the players.

Local jobless rates up while state's rate continues to improve
The Department of Employment and Workforce said Friday that South Carolina's unemployment rate was 4 percent in June. Other sectors losing jobs over the month were manufacturing; other services; and trade, transportation and utilities.

Donald Trump sacks Priebus, names new WH Chief of Staff
While the secretary of state sought to quell tensions, Trump came out with a tweet that essentially sided with the Saudis. But it had been obvious for some time from news reports that Priebus seemed to be on thin ice in the Trump White House.

Motorola Moto Z2 Force Edition launched with shatterproof display
In the single-core test, the alleged Moto X4 got 824 points while in the multi-core testing the device has acquired 3886 points. The Moto Z2 Force Edition will hit availability in the US on August 10 via US Cellular, Verizon , AT&T , T-Mobile, and Sprint .

45 senators call on Mattis to resist Trump's transgender military ban
Those sentiments are now playing out on a more national stage, and if Friday's poll is any indicator, with potential repercussions for Trump.

Captain Marvel reveals include '90s setting and villain
Though Marvel hasn't sent official stills yet, several Hall H audience members shared photos from inside the convention. In the regular Marvel Comics continuity, Carol Danvers made her first appearance in 1968's Marvel Super-Heroes #13.

Man City defender opens up about struggles under Pep Guardiola
Iheanacho is on the verge of joining Leicester City after dropping down the pecking order in Guardiola's Manchester City attack. Spurs' only win in the competition came against Paris St-Germain, with Saturday's defeat adding to a loss against Roma.

Samsung officially introduces the SM-G9298 flip phone
There are many sensors on board, some of which include an acceleration sensor, a gyroscope, and a barometric pressure sensor. Similar to the Samsung Galaxy S8 and Galaxy S8+, the flip phone does not come with a dedicated button for Samsung's Bixby.